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Michael D.
Corbett, Ph.D. |
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RESEARCH CONTRIBUTIONS Fundamental contributions to the fields of Organic Chemistry and Biochemistry have been the discovery of two new chemical reactions. These new reactions were discovered during the course of experimentation designed to further understand how chemicals of the arylamine and nitroaromatic classes of organic chemicals might cause disease. The significance and value of these discoveries extend far beyond the field of Chemical Toxicology & Carcinogenesis alone. The first discovery occurred in 1974 while on the Pharmacy Faculty of the University of Mississippi. The further study of this Bioorganic chemical reaction continued throughout my academic career. For lack of a better name, the reaction is now called: The Nitroso-Shunt Pathway which is simpler, but less descriptive than my original name for the discovery, which was: The Adventitious Reaction of Nitrosoarenes with Intermediates of Thiamine-Dependent Enzymes. Details (under construction) Several years later, while doing additional research on the first discovery, another somewhat serendipitous discovery was made. This occurred during my tenure as an 'oceanographer' at the University of Miami. The result was a new organic chemical reaction now known as: The Nitroso-Glyoxylate Reaction Details (under construction) Other Notable Contributions Elucidation of the N-Oxygenase
Action of Chloroperoxidase Details (under construction) Contribution of Human Granulocytic
Cells to the Genotoxicity of Arylamine Chemicals Details (under construction) Methods Development in Analytical
Organic Chemistry and Biochemistry Details (under construction) |