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TEACHING
EXPERIENCE
Principal Assignments at the University of
Mississippi
Undergraduate:
Pharmacognosy 425: Four semester hour course for fourth year pharmacy students on
the chemistry, pharmacological actions and clinical uses of alkaloids and glycosides.
Examples of such natural product drugs are morphine, cocaine, lysergic
acid, reserpine, atropine, quinine, strychnine
and digitalis. Laboratory experimentation included: "The Isolation and
Analysis of Morphine Alkaloids from Pharmaceutical (U.S.P.) Opium" and "Botanical
and Chemical Identification of Marijuana".
Pharmacognosy 426: Four semester hour course on the chemistry, biological actions
and clinical uses of antibiotics and antitumor agents. Examples are the penicillin,
cephalosporin and tetracycline families of antibiotics, streptomycin,
erythromycin and chloramphenicol. An example of a valuable antitumor
drug from natural sources is vincristine, which was a major breakthrough in the
treatment of childhood leukemias. Additional topics included the principles of immunology
and the use of immunizing biologicals. Laboratory experimentation included: "The
Production of Penicillin-G in Submerged Culture", "Solubility
Properties of Pen-G Salts" and "The Investigation of Tetracycline
Stabilty".
Graduate:
Pharmacognosy 631: Three semester hour course on modern isolation and analytical
techniques applied to organic chemistry and biochemistry. Emphasis on the theory and
practice of chromatography, including ion exchange, gel permeation and affinity methods.
Pharmacognosy 632: Three semester hour course on structure elucidation by
instrumental methods. Emphasis on the application of infrared, nuclear magnetic resonance
and mass spectroscopy to natural products.
Pharmacognosy 620: Special topics including Bioorganic Reaction Mechanisms,
Chemical Toxicology and Metabolism, and Marine Natural Products.
Principal Assignments at the
University of Miami
Graduate:
Marine Organic Chemistry: Three semester hour course on the chemistry and biosynthesis of
marine natural products; Chemical ecology; Organic chemical pollution of marine
environments with emphasis on natural processes that effect the degradation of organic
chemicals in the environment.
Principal Assignments at the
University of Florida
Graduate:
FSHN 6236 (Biochemical Toxicology): Three semester hour course on the application of chemistry and
biochemistry to the field of toxicology. Emphasis on the mechanistic aspects of
bioactivation and detoxification of genotoxic (mutagenic, carcinogenic)
and necrotizing organic chemicals. Xenobiotic metabolism and covalent binding of reactive
species to cellular nucleic acids and protein. The role of oxygen metabolism and free
radicals in pathology and in xenobiotic metabolism and toxicity. Current theories in
cancer causation by chemicals.
Lecture Assignments at the
University of Nebraska Medical Center
Graduate:
PHSC 688/888 (Concepts in Toxicology): Lectures in the areas of peroxidation/oxygen pathology and
bioactivation mechanisms of xenobiotics.
PHSC 950 (Advanced Toxicology): Lectures in the area of reactive oxygen species as related to
toxicology.
PHSC 875 (Chemical Carcinogenesis): Lectured on the arylamine group of carcinogens.
BIOC880 (Methods in Cancer Research): The role of metabolism in chemical carcinogenesis.
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